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A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial development.
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For implementers, backpressure adds complexity without providing guarantees. The machinery to track queue sizes, compute desiredSize, and invoke pull() at the right times must all be implemented correctly. However, since these signals are advisory, all that work doesn't actually prevent the problems backpressure is supposed to solve.